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Corna, G

Ann Oncol 24(11):2844-9, 2013

We don't have robust long-term data on: What happens to muscle mass and bone density over 5-10 years of use The impact on people who start these medications in their 20s or 30s Impact on fertility/reproductive outcomes Early data is showing that GLP-1 might help in PCOS, but what about long-term hormonal regulation

Intestinal glucose infusion increases portal levels of GLP-1, and coinfusion of exendin-9, a GLP-1R antagonist, abolishes the ability of both intestinal fatty acids and glucose infusion to lower hepatic glucose production 130,131