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If you have thyroid issues, tirzepatide and thyroid nodules require specific evaluation before starting combination therapy

Beta-blockers (propranolol) have been shown to augment GH responses to various stimuli by blocking beta-adrenergic inhibition of GH release [17]

Sample 8-Week Starting Protocol | Time | Ipamorelin | GHK-Cu | |------|-----------|--------| | Bedtime (fasted) | 200 mcg SQ | 1 mg SQ | | Morning (optional, fasted) | 200 mcg SQ | Skip or 1 mg topical | | Duration | 8 weeks | 8 weeks | | Washout | 4 weeks | 2 weeks (shorter, no pituitary axis concern) | Dose adjustments should be guided by IGF-1 levels drawn at week 4 (see Monitoring section below)

Tell them your symptoms, especially if you have a fever, diarrhea or pain