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doi: 10.1186/s12970-014-0064-5, 20

Notable examples include miR-99b, which alters expression of AR, the AR-associated coregulator SMARCD1 [111] and the AR target gene PSA [108, 112]

Potential implications for insurers Insurers may want to consider the implications of AOMs for their business: Review trend assumptions to identify whether changes are needed Consider new lapse risks Assess how AOMs might affect underwriting and claims Establish processes to keep on top of this fast-moving space Reviewing mortality improvement assumptions An insurer's current mortality trend assumptions likely include anticipated improvements from drivers such as medical advances

Some people report feeling unusually warm or notice slight increases in heart rate, which aligns with the glucagon receptor activation increasing energy expenditure