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Moreover, intra-VTA Ex-4 (0.05 g/kg) also reduced cocaine-seeking dose-dependently but did not affect sucrose seeking (Schmidt et al., 2016

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We then focused on the entire list of miR-4488-down-regulated genes irrespective of their cluster origin, ending up with a set of 409 genes that were significantly down-regulated (t = 48 miR-4488 versus t = 48 miR-CTRL, fold change of 1.5 or less and q-value of 0.05 or less)