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In isolated liver mitochondria, zinc reversibly inhibits KGDHC-dependent respiration, demonstrating a mechanistic link between matrix zinc levels and metabolic flux 86

Validating robust, non-invasive biomarkers (e.g., circulating lipid peroxide metabolites, urine exosomal ferroptosis regulators, or TME-derived immune cell ferroptosis signatures) is urgently needed to guide clinical trial design and patient stratification

The human brain and spinal cord are composed of multiple cell types, including neural parenchymal cells (neurones and neuroglia) that form the active networks responsible for the functional output and a variety of supporting stromal cells (endothelial, pericytes, fibroblasts etc.) (Fig

This article examines what each compound is, how they work, the current evidence base, and the significant regulatory and safety considerations UK patients and clinicians need to understand