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When GSH becomes oxidized, a disulfide bond forms between two GSH molecules, which become oxidized glutathione (GSSG)

Investigating the mechanisms underlying this interaction holds significant value

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AGEs promote the accumulation and cross-linking of extracellular matrix (ECM) proteins, contributing to vascular sclerosis and fibrosis, which further progress to diabetic cardiomyopathy and diabetic nephropathy [32,33,34,35]