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Since many individuals with Hashimoto's experience weight gain and difficulty losing weight despite adequate thyroid hormone replacement, the appetite-suppressing properties of GLP-1 agonists may appear attractive

It is now a mainstream pathway for initiating therapy

Rescued with Wnt agonist BML-284 demonstrated a central role of this pathway by recovering caudatin-mediated inhibition of glycolysis and EMT (Epithelial-Mesenchymal Transition) markers (Table 1, Row 2)