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Therefore, to achieve a more accurate result, sKlotho measurement should be conducted repeatedly and averaged, and the sKlotho value should be obtained after eliminating or balancing the influence of other potential regulators, including inflammation, drugs, RAS and extra-kidney organs, in the study design
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This is a crucial issue in part because patients who discontinue use of GLP-1s tend to regain much or all of the weight they lost while taking the drug, according to several studies, including a meta-analysis by researchers at Englands University of Oxford
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