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The upregulation and activation of 7nAChR subsequently activate several signaling pathways, including neuroprotective PI3K/Akt and Nrf2 pathways, then suppression of pro-apoptotic caspase-3, and suppression of NF-B that reduce the expression of proinflammatory cytokines such as IL-1, and TNF- [50, 86]

Additionally, the European Commission advanced chronic-disease initiatives in 2024, including digital metabolic-care tools that integrate GLP-1 adherence, reflecting a shift toward long-term management

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