BPC-157 reverses short bowel syndrome manifestations in animal models, promoting constant weight gain above preoperative values and increasing villus height, crypt depth, and muscle layer thickness in the remaining intestinal tissue
This means the problem is not caused by just one factor, but by several changes happening at the same time
and reducing stellate cell activation, potentially reducing their fibrotic response to liver injury [37]
Primarily, hypothyroidism itself adversely affects gastrointestinal physiology by diminishing gastric mucosal integrity and reducing gastric acid secretion, thereby impairing the efficient absorption of nutrients and trace elements critical for thyroid function, such as selenium, iodine, iron, zinc, and vitamin D (Shulhai et al., 2024)