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Although the WHO MPN category includes seven subcategories, the term MPN usually refers to the three JAK2 mutation-enriched clinicopathologic entities: PV, essential thrombocythemia (ET) and primary myelofibrosis (PMF) 1

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The conjugate delivers lanifibranor at 6,898 times less of the standard preclinical dose

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It occurs when the rate of generation of reactive oxygen species (ROS) is too high to be countered by natural antioxidant defence mechanisms, resulting in cellular and molecular damage within wound tissue

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