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156 Mitophagy, 157 mitochondrial dynamics, 158 and mitochondrial biogenesis 158 are also affected in patients with AD, ultimately resulting in the accumulation of dysfunctional mitochondria and mitochondrial fragmentation

Next, GS-4997, a specific ASK1 inhibitor, was used to confirm that the expression of SREBF1 and PLIN2 is regulated by ASK1-p38/JNK signalling

Future research must address the gaps in biomarkers, subphenotype-specific mechanisms, and the integration of ferroptosis-targeted therapies into standard care