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The 22-nt long mature miRNA strand obtained from the intermediate duplex is then loaded into the Argonaute-containing RNA-induced silencing complex (RISC) and target mRNA molecules by miRNA:mRNA sequence complementarity and negatively affects gene expression either through mRNA cleavage and degradation via the perfect base-pairing with target mRNA or translation repression via imperfect complementation with 3UTR of target mRNA (Smith-Vikos and Slack, 2012)

Aging Cell 18 , e12895 (2019)

Kovalovich K, DeAngelis RA, Li W, Furth EE, Ciliberto G, Taub R

The study showed a positive effect of melatonin received by group 1 subjects on insulin levels, general mental well-being, LDL indicators, and cholesterol levels ( Table 2 ) (141)