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(6) neurotrophic agents offer the ability to facilitate synaptogenesis, neurogenesis and neuroprotection thus greater research attention must be directed toward creating small molecule analogs designed to penetrate the BBB and activate these brain systems

Using an SGLT2i with a drug like Telmisartan can inpact PPAR alpha and PPAR gamma, affecting everything from sympathetic overactivation to insulin resistance to mitochondrial dysfunction

It is a complex network of interlocking genetic feedback loops involving clock genes (Clock, Bmal1), period genes (Per1, Per2, Per3), and cryptochrome genes (Cry1, Cry2)

There may not be extensive use due to this financial obstacle and worries about injections