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This occurs at 4-5 half lives because once that time is reached, every dose that goes IN will ultimately be gone in 4-5 half lives

Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)

Improved Blood Sugar Control: These peptides help regulate blood glucose levels, making them beneficial for individuals with type 2 diabetes or insulin resistance

Erratic schedules prevent GI adaptation and increase nausea severity