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doi:10.15585/mmwr.ss7007a1

BMC Endocr Disord 26 , 86 (2026)

70 The European Medicines Agencys Pharmacovigilance Risk Assessment committee recommended risk minimization measures (RMM) for flupirtine (use only after other analgesics were trialled, patients restricted to up to two week-long treatments, with weekly LFT) due to concern of rare serious liver injury associated with long-term use of flupirtine

Many of the paper and pencil questionnaires employed to assess cognitive abilities may not be sensitive enough to detect small changes that result from short-term interventions of micronutrient supplementation (101, 102)