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USP20 inhibitors, including GSK2643953A, reduce obesity, improve glucose tolerance, and alleviate hepatic lipid accumulation in high-fat-diet mouse models

Nature 597 , 709714 (2021)

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L-Carnitine is actually a transport molecule responsible for transporting fatty acids to the mitochondria to be metabolized, which theoretically means a reduction in its bodily levels could compromise the bodys ability to metabolize fatty acids perhaps increasing the likelihood they end up stored on the liver