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reuteri ), which has a protective effect against dextran sulfate sodium-induced colitis in mice, increasing the mucus layer thickness ( Specific probiotic-modulated local and systemic metabolites have been reported to have anti-inflammatory and antimicrobial functions, such as SCFA, dietary tryptophan, adenosine, and histamine (Liu, Alookaran, et al., 2018)

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Ex vivo skin permeation experiments also showed that HA functionalization improved drug distribution within the skin, with higher dermal retention, lower surface residue, and controlled permeation across the tissue