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David, Hamilton Debby, Guthrie Najla and Evans Malkanthi*, An Open-label Exploratory Study Investigating BDNF Essentials on Cognition in Healthy Adults with Self-reported Memory Complaints, Current Nutraceuticals 2023

To place the relevance of these differences in context, aging-related reduction in LM in older individuals ranges from 1 to 3 kg per decade, depending upon age and other factors

[1] It goes without saying that we don't suggest such astronomical doses (37.5mg/kg is nearly a 3g dose), but it's interesting to see that the researchers even bring up the excessive sweat and salivation

But when you'll actually start feeling the effects of stopping is a different question