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Notably, the MC4R agonist setmelanotide (IMCIVREE) was recently approved by the US FDA to manage BBS-associated weight gain and is under evaluation for additional therapeutic effects in BBS patients (45, 46)

doi: 10.1289/ehp1774 Summary Keywords environmental endocrine disruptors, male fertility, sperm quality, epigenetics, reproductive toxicology Citation Han X and Jin X (2025) The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health