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Changes in physiological parameters, including HbA1c, systolic blood pressure, BMI, high- and low-density lipoprotein cholesterol, and estimated glomerular filtration rate (eGFR), as well as hypoglycemic event rates, were sourced from the oral semaglutide 14 mg and liraglutide 1.8 mg arms of PIONEER 4, with means and standard deviations evaluated by the trial product estimand at 52 weeks informing sampling around each treatment effect for each modeled patient (Table 2) [11]