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The STEP 1 trial led by John Wilding, published in the New England Journal of Medicine in 2021, randomised 1,961 adults with overweight or obesity to once-weekly semaglutide titrated to 2.4mg or placebo, and found a mean weight loss of about 14.9% over 68 weeks against roughly 2.4% on placebo (Wilding et al., 2021)

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Vitamin B12 and Folate July 16, 2026 Key points Vitamin B12 and folate are vitamins that serve important functions in the human body