Healthy growing follicles exhibit resistance to granulosa cells apoptosis, whereas in early atretic follicles, apoptosis begins in the inner granulosa cells layer and progressively affects most granulosa cells, leading to follicular atresia (Tilly et al., 1991)

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Gross necropsy and histopathologic examination found no organ damage in liver, spleen, lung, kidney, brain, thymus, prostate, ovaries, or gastric wall
Furthermore, a follow-up study in Germany has indicated that VTP therapy is a promising treatment option for patients with unilateral low-risk PCa (148)