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Randomization took place after a 6-week run-in period consisting of a 3-week forced metformin and glimepiride titration period followed by a maintenance period of another 3 weeks

The research tests a theory that states the human body's GLP-1 pathways function within joint tissues to control joint inflammation that occurs during osteoarthritis and rheumatoid arthritis

To assess the presence of residual/unmeasured confounding, we chose kidney stone as a negative control outcome and repeated the analysis, as there is no known effect of GLP-1RA on kidney stone

Note the lack of a plateau of weight-loss effect in these trials at 36 and 48 weeks, respectively