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The combination of hepsin with NAC shows a synergistic effect, providing more effective protection than NAC alone, thus offering new avenues for enhancing current treatment approaches

Cyclin-dependent kinase 2 (CDK2), B-cell lymphoma-2 (BCL-2) and Hypoxia-inducible factor 1-alpha (HIF-1) are such genes that are regulated by MITF

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3 Evolution of GLP-1-based therapeutics 3.1 First-generation GLP-1RAs The development of GLP-1 receptor agonists stemmed from the significant finding that natural GLP-1 had an exceptionally short half-life of about 1.5 to 5 min, due to its rapid degradation by the enzyme DPP-4 (Campbell and Drucker 2013) (Fig