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Contact of the patients blood with the non-endothelial surfaces is equivalent to contact with an exogenous foreign body, which triggers the activation of the bodys rejection mechanism and a series of other reactions, such as the induction of an immune inflammatory response, oxidative stress, and activation of the coagulation system, as well as changes in body cells including vascular endothelial cells, leukocytes, and platelets

Aged hearts exhibit reduced activity of complexes I and IV, decreased mitochondrial membrane potential, and lower ATP synthesis capacity, collectively termed bioenergetic decline

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