Intensity of behavioral disturbances and seizure presentation assessment After paracetamol application, intensity of progressing behavioral disturbances and seizure presentation was continuously monitored, and assessed and scored (score 0 - normal, score 1 - rearing on hind legs, shaking, 2 - sleepy, tottering walk, 3 - sleepy, tottering walk and repeatedly falling down, 4 - sleepy, tottering walk and repeatedly falling down, jerking of the extremities, 5 - lying down, generalized convulsions) at particular time points depending on the regimen used, as described before
The CBP lysine acetyltransferase is a well-recognized, direct NRF2 binding partner (Tonelli et al, 2018), contributing to NRF2 transcriptional activity at reporter genes (Katoh et al, 2001) and responsible for acetylating NRF2 itself (Sun et al, 2009)
GHK-Cu (glycyl-L-histidyl-L-lysinecopper) is a naturally occurring tripeptidea molecule made of three amino acidsthat has a powerful ability to bind copper ions (specifically copper(II))
While formal clinical trials in humans are limited and the compound is not FDA-approved, early preclinical studies and anecdotal reports suggest it may play a role in supporting the bodys natural healing processes