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Mild heat-related illnesses can occur in normothermic individuals, with symptoms ranging from transient unconsciousness (heat syncope) to fatigue and dizziness (heat exhaustion) [5]

In addition, a systematic umbrella review, which examined the major areas of research regarding the hypothesis that serotonin is deficient during depression, found no evidence that brain deficiency or low activity of the neurotransmitter is at the root of the psychiatric disorder [10]

The activation of TGR5 receptors by secondary bile acids inhibits NLRP3 inflammasome activation via the cAMP-PKA pathway, promotes macrophage polarization towards the M2 phenotype and attenuates the inflammatory response 148

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