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In the collaborative and translational DECLARED project supported by the Swiss National Science Foundation , we test the overarching research hypothesis whether the menopausal decline in estradiol disrupts the GLP-1 gut-pancreas/brain axis, predisposing to or worsening type 2 diabetes

This means it activates three key hormone receptors in the body

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Weight loss injections, primarily glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide (Wegovy), liraglutide (Saxenda), and the newer tirzepatide (Zepbound), have become increasingly prominent in the management of obesity in the United Kingdom