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This coordinated engagement across the pancreas, brain, gut, liver, and adipose tissue underlies the mechanistic rationale for dual GLP-1/GIP receptor agonists, and explains why they have been described as super GLP-1RAs, reflecting genuine potentiation of GLP-1 action by GIP receptor agonist co-activation

Signs of oxidative damage to proteins, lipids, and DNA have been found in blood [35, 112], urine [113], and post-mortem brain samples [79, 80] collected from autistic individuals

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Identification of new indications for FDA-approved medications can occur in a serendipitous fashion in which a drug shows unexpected benefits in clinical trials for its original indication