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The protective effects of TQ under oxidative stress are largely mediated by stimulating the expression of the Nrf2 gene and inducing nuclear translocation of Nrf2, as depicted in Figure 5

In conclusion, LDHB silencing results in decreased viability and colony formation capacity in cancer cell lines from different genetic backgrounds and tissues of origin and is associated with increased lipid peroxidation, particularly mitochondrial lipid peroxidation, accompanied by changes in mitochondrial morphology, all characteristics associated with ferroptosis

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Monteiro-Soares, M