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[6] [42] [43] For single doses of lipophilic, multi-compartment drugs, clinical duration after onset is often driven by the distribution () phase, because by the time distribution equilibrium is reached plasma levels are frequently below any minimal effective concentration, so the terminal phase has little bearing on observable effects
However, individual results can vary based on diet, physical activity, medication adherence, and unique metabolic factors
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This reasoning is partially correct but dangerously incomplete
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