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Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

Melatonin is a prescription-only medicine in the UK, with the licensed product being Circadin 2 mg prolonged-release tablets

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When researchers considered the SIR over time, particularly among those under 65 years of age, the elevated risk remained significant, 5 years after the date of their TC diagnosis (SIR = 2.08, 95% CI 1.5 2.66) although it was non-significant among those over 65 years of age (SIR = 1.0, 95% CI 0.57 1.42)