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For most patients, the benefits of improved blood sugar control and weight loss likely outweigh the inconvenience of feeling cold

It is a bone-deep weariness that makes the idea of physical activity, including sex, feel overwhelming rather than appealing

A recent meta-analysis conducted by Winterlind, encompassing nine randomized controlled trials, found no notable advantage of NAC over placebo in alleviating cravings across various substance use disorders, despite its well-established modulation of glutamatergic and dopaminergic systems [81]