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The occurrence of ferroptosis in mature erythrocytes has not been confirmed and it seems quite challenging, since ferroptosis studies suffer from the lack of well-established markers and evaluation of this cell death requires a complex approach with identification of typical cellular and subcellular morphological alterations, genetic hallmarks, biochemical changes, expression of certain ferroptosis-related proteins, etc

My work has always been about translating evidence, not monetising hype

& Sporn, M

Also, an important part of their activity can be attributed to the generation of diverse microbiome-derived metabolites (Setchell et al., 2002