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Expected 12-month results include 15 to 22% body weight loss (50 to 75 pounds for a 300-pound person), 5 to 8 inch waist circumference reduction, major improvement in mobility and physical function, and often dramatic improvement or resolution of obesity-related health conditions including sleep apnea, fatty liver disease, and joint pain

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The maintenance pill The ATTAIN-MAINTAIN trial involved participants from the companys earlier SURMOUNT-5 study, which directly compared semaglutide and tirzepatide