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values for ELISA assay samples were measured using a Benchmark Plus plate-reading spectrophotometer under the control of Microplate Manager software (Bio-Rad Laboratories, Hercules, CA)

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958 For example, high throughput selection and counter-selection strategies have led to the development of metal ion-specific DNAzymes with unprecedented metal specificity that continue to teach us how nucleic acids distinguish among various transition metal ions, while also creating reagents for applications as biosensing tools