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Altered expression of the clock gene causes a loss of timely coordination among different brain areas, interferes with the regulation of basic cellular metabolic and homeostatic processes, and ultimately results in the disruption of connections among brain structures, ultimately leading to cognitive impairment and the characteristic chrono-disruption seen at the onset of early neurodegenerative diseases in patients

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Mechanism study: By activating the PI3K/Akt pathway, inhibiting GSK-3 activity, and reducing tau protein hyperphosphorylation

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