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Cardiovascular Safety Studies With DPP-4 Inhibitors The Clinical Guidance for Pharmaceutical IndustryDiabetes MellitusEvaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes established by the FDA in 2008 as a consequence of adverse safety signals of rosiglitazone has set up the requirement for novel diabetes medications to prove cardiovascular safety of these substances in comparison to standard therapy under glycaemic equipoise

The details of these trials are summarized in Table 1

Cytochrome c binds to Apaf1 and dATP to form apoptosomes, which in turn activate caspase9 and downstream effector caspases