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For example, the downregulation of specific genes, particularly those involved in neurotransmitter synthesis and metabolism, such as the serotonin transporter gene (SLC6A4) and BDNF, is closely linked to depression onset [364]

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Acknowledgements We are grateful for the support from the Laboratory Animal Center at National Taiwan University, College of Medicine and Flow Cytometric Analyzing and Sorting Core of the First Core Laboratory, National Taiwan University College of Medicine for providing the service