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Another study, which investigated the prevalence of hypersensitivity in cheilitis patients demonstrated increased serum total IgE level and positive food-specific IgG in cheilitis patients compared to the healthy control 16

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Hemolytic anemia is the main pathological manifestation of -thal, and hemolysis occurs for two reasons: premature destruction of erythroid precursor cells, and shortening of the lifespan of mature erythrocytes in the circulation ( Anemia in individuals who have -thal is primarily triggered by ineffective erythropoiesis (IE)