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Similarly, targeting the central ferroptosis inhibitor SLC7A11, the expression of which is upregulated via the MISP/MST/yes-associated protein signaling pathway, represents a rational strategy to sensitize cells to ferroptosis (109)

The Regulatory Impact Analysis of the HEBA from the CY 2025 PFS final rule (89 FR 98523 and 98524) estimated that total net savings is projected to grow over ten years by approximately $260 million as a result of the HEBA attracting additional high-cost ACOs to join the program and creating savings for the Medicare program, ranging from a $1.2 billion cost to a $2.2 billion savings at the 10th and 90th percentiles

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So the GLP-1 outcomes are commercially useful