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Infections may remain asymptomatic for a period before manifesting as nodules accompanied by redness, tenderness, or abscess formation

The "52-week window" refers to the timeframe of the Hansen et al

As discussed above, endogenous GLP-1 is rapidly degraded by DPP-4, whereby it loses its insulinotropic activity, and preventing this degradation results in increased intact GLP-1 levels, improved pancreatic islet responses (enhanced insulin and suppressed glucagon levels) and beneficial effects on glucose homeostasis

Although delivering a gene with a viral vector can alleviate the situation to some extent, it will bring extra stress on the cells, interact with endogenous cellular signal transduction components and cause cytotoxicity (Wu et al., 2021)