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These pathways converge at the central metabolic intermediate crotonyl-CoA, with distinct synthesizing enzymes participating in each path: crotonase (Cro), 4-hydroxybutyryl dehydratase (4hbD), glutaconyl-CoA decarboxylase (Gcd), or 3-aminobutyryl-CoA ammonia lyase (Kal) (Fig

Efficacy and safety of IDegLira versus basalbolus insulin therapy in patients with type 2 diabetes uncontrolled on metformin and basal insulin