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Some conditions that are treated with arginine are chest pain, atherosclerosis (clogged arteries), heart disease or failure, erectile dysfunction, intermittent claudication/peripheral vascular disease, and vascular headaches (headache-inducing blood vessel swelling)

Glucose Homeostasis Studied extensively for its effects on insulin secretion, glucose-dependent insulinotropic activity, and overall glycaemic control in both animal models and early-phase human trials

Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]