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Alcohol- and other substance-use disorders may well benefit from the effects of GLP-1RAs on dopamine and opioid pathways that are dysregulated in addiction 243 , as seen in some of the studies we identified, and the same could also apply to other under-investigated disorders with similar underlying dysfunctions (for example, gambling disorder)

In terms of diagnosis, the available dumping syndrome severity questionnaires are not considered reliable enough to aid in the diagnostic process (statements 2127)