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In a randomized, double-blind, placebo-controlled trial, Arjinpathana and Asawanonda demonstrated that participants taking 500 mg of oral glutathione daily exhibited significantly lower melanin levels in sun-exposed areas, such as the face and wrists, compared to the control group [12]

When prescribed for weight loss, this constitutes off-label usea practice permitted under medical judgment but outside the FDA-approved indication

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