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doi: 10.1126/scitranslmed.abb6981 237 JeanbartLBallesterMde TittaACorthsyPRomeroPHubbellJAet al

In the same study, the genetic deletion in the oocyte of a specific enzyme Pdss2 (leading to its inactivation), involved in the CoQ10 synthesis led to aged oocytes in young mice with: Premature ovarian failure Reduction of follicle number Poor ovulation response to stimulation Decreased ATP production and mitochondrial activity in the few aged oocytes

Valproate should not be used to treat women with epilepsy or bipolar disorder who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptable