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A structure-based assignment of the glutathione activator site without transition-state analogues is much more difficult because of labile GSH interactions 2 that likely depend not only on the presence of the first glutathione moiety but also on conformational changes of the glutathionylated enzyme 3,12,37,44
Hayashi, T., Yamashita, T., Watanabe, H., Kami, K., Yoshida, N., Tabata, T., Emoto, T., Sasaki, N., Mizoguchi, T., Irino, Y., Toh, R., Shinohara, M., Okada, Y., Ogawa, W., Yamada, T., & Hirata, K
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