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One cause of such a cytokine storm is an imbalance of the ratio between ACE1 (the pro-inflammatory mediator) and ACE2 (the anti-inflammatory mediator)

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Enzo Spisni, [email protected] These authors have contributed equally to this work $ These authors have contributed equally to this work and share last authorship ORCID: Fabio Vivarelli, orcid.org/0000-0002-8734-0985 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers